Arsenic trioxide - An old drug rediscovered. Current standard treatment of adult acute promyelocytic leukaemia. Arsenic poisoning caused by intentional contamination of coffee at a church gathering--an epidemiological approach to a forensic investigation.
Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. September Learn how and when to remove this template message Common symptoms of mercury poisoning include peripheral neuropathypresenting as paresthesia or itchingburning, painor even a sensation that resembles small insects crawling on or under the skin formication ; skin discoloration pink cheeks, fingertips and toes ; swelling; and desquamation shedding or peeling of skin.
Mercury irreversibly inhibits selenium -dependent enzymes see below and may also inactivate S-adenosyl-methioninewhich is necessary for catecholamine catabolism by catechol-O-methyl transferase. Due to the body's inability to degrade catecholamines e.
Affected children may show red cheeksnose and lips, loss of hairteethand nailstransient rashes, hypotonia muscle weaknessand increased sensitivity to light.
Other symptoms may include kidney dysfunction e. Fanconi syndrome or neuropsychiatric symptoms such as emotional labilitymemory impairment, or insomnia. Thus, the clinical presentation may resemble pheochromocytoma or Kawasaki disease.
Desquamation skin peeling can occur with severe mercury poisoning acquired by handling elemental mercury. Tetsuya Endo, a professor at the Health Sciences University of Hokkaidohas tested whale meat purchased in the whaling town of Taiji and found mercury levels more than 20 times the acceptable Japanese standard.
An estimated two-thirds of human-generated mercury comes from stationary combustion, mostly of coal. Other important human-generated sources include gold productionnonferrous metal production, cement production, waste disposalhuman crematoriacaustic soda production, pig iron and steel production, mercury production mostly for batteriesand biomass burning.
Such is the danger for the galamsey in Ghana and similar workers known as orpailleurs in neighboring francophone countries. While no official government estimates of the labor force have been made, observers believe 20,—50, work as galamseys in Ghana, a figure including many women, who work as porters.
Similar problems have been reported amongst the gold miners of Indonesia. Mercury and its compounds are commonly used in chemical laboratories, hospitals, dental clinics, and facilities involved in the production of items such as fluorescent light bulbs, batteries, and explosives.
These compounds have been implicated in causing brain and liver damage. The most dangerous mercury compound, dimethylmercuryis so toxic that even a few microliters spilled on the skin, or even on a latex glove, can cause death.
Mercury in fish Methylmercury is the major source of organic mercury for all individuals. Top predatory fish, such as tuna or swordfishare usually of greater concern than smaller species. The longest recorded latent period is five months after a single exposure, in the Dartmouth case see History ; other latent periods in the range of weeks to months have also been reported.
No explanation for this long latent period is known. When the first symptom appears, typically paresthesia a tingling or numbness in the skinit is followed rapidly by more severe effects, sometimes ending in coma and death.
The toxic damage appears to be determined by the peak value of mercury, not the length of the exposure. Prefrontal cortex or dopamine neurotransmission could be especially sensitive to even subtle gestational methylmercury exposure  and suggests that public health assessments of methylmercury based on intellectual performance may underestimate the impact of methylmercury in public health.
Ethylmercury is a breakdown product of the antibacteriological agent ethylmercurithiosalicylate, which has been used as a topical antiseptic and a vaccine preservative further discussed under Thiomersal below. Its characteristics have not been studied as extensively as those of methylmercury.
It is cleared from the blood much more rapidly, with a half-life of seven to 10 days, and it is metabolized much more quickly than methylmercury. It is presumed not to have methylmercury's ability to cross the blood—brain barrier via a transporter, but instead relies on simple diffusion to enter the brain.
These compounds were used in indoor latex paints for their antimildew properties, but were removed in because of cases of toxicity.
Because they are more soluble in water, mercuric salts are usually more acutely toxic than mercurous salts. Their higher solubility lets them be more readily absorbed from the gastrointestinal tract. Mercury salts affect primarily the gastrointestinal tract and the kidneysand can cause severe kidney damage; however, as they cannot cross the blood—brain barrier easily, these salts inflict little neurological damage without continuous or heavy exposure.
Its vapor is the most hazardous form. Animal data indicate less than 0. Cases of systemic toxicity from accidental swallowing are rare, and attempted suicide via intravenous injection does not appear to result in systemic toxicity,  though it still causes damage by physically blocking blood vessels both at the site of injection and the lungs.This topic has 90 study abstracts on Ginger indicating that it may have therapeutic value in the treatment of Osteoarthritis: Knee, Nausea, and Chemotherapy-Induced Nausea.
Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. If arsenic poisoning occurs over a brief period of time symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood.
Long-term exposure can result in thickening of the skin, darker skin, abdominal pain, diarrhea, heart disease, numbness, and cancer. Lead, Mercury, Cadmium and Arsenic in the Environment Edited by T.
C. Hutchinson and K. M. Meema The overt toxicity of these elements has been recognized for many years; indeed, the harmful effects of lead were known as far back as the second Human Health Concerns of Lead, . Ayurvedic medicine (also called Ayurveda) is one of the world’s oldest medical leslutinsduphoenix.com originated in India more than 3, years ago and remains one of the country’s traditional health care systems.
Its concepts about health and disease promote the use of herbal . Toxicity Toxicity and Complications of Breast Implants - Personal Stories of Healing. The most serious complications from Saline or Silicone breast implants include toxic shock syndrome, implants breaking through the skin, or skin dying.
Suggested Citation:"Case Study 1: Arsenic Toxicity."Institute of Medicine. Environmental Medicine: Integrating a Missing Element into Medical Education.